A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection

 Primary cytomegalovirus (CMV) infection during pregnancy carries a risk of congenital infection and possible severe sequelae. There is no established intervention for preventing congenital CMV infection.

 In this multicenter, double-blind trial, pregnant women with primary CMV infection diagnosed before 24 weeks’ gestation were randomly assigned to receive a monthly infusion of CMV hyperimmune globulin (at a dose of 100 mg per kilogram of body weight) or matching placebo until delivery. The primary outcome was a composite of congenital CMV infection or fetal or neonatal death if CMV testing of the fetus or neonate was not performed.

Among pregnant women, administration of CMV hyperimmune globulin starting before 24 weeks’ gestation did not result in a lower incidence of a composite of congenital CMV infection or perinatal death than placebo.


Comments

Post a Comment

Popular posts from this blog

Variant PNLDC1, Defective piRNA Processing, and Azoospermia

Image
  P-element– precipitated wimpy testis (PIWI)–interacting RNAs (piRNAs) are short (21to 35 nucleotides in length) and noncoding and are observed nearly solely in germ cells, in which they adjust aberrant expression of transposable factors and post meiotic gene expression. Critical to the processing of piRNAs is the protein poly(A)- precise RNase-like area containing 1 (PNLDC1), which trims their 3′ ends and, whilst disrupted in mice, reasons azoospermia and male infertility. We carried out exome sequencing on DNA samples from 924 guys who had obtained an analysis of nonobstructive azoospermia. Testicular-biopsysamples have been analyzed through histologic, immunohistochemical hybridization, reverse-transcriptase–quantitative-polymerase-chain- response assay, and small-RNA sequencing Four unrelated guys of Middle Eastern descent who had nonobstructive azoospermia have been discovered to hold mutations in PNLDC1: the primary affected person had a biallelic stop–ad...
Read more

Neutralizing antibodies and cytokines in breast milk after mRNA vaccination against 2019 coronavirus infection (COVID19).

Image
Evaluation of immune response to mRNA-based vaccine against coronavirus disease 2019 (COVID19) present in breast milk and transmission of immune response to breast-fed infants We enrolled 30 lactating women who received mRNAbased COVID19 vaccines from January through April 2021 in this cohort study. Women provided serial milk samples, including milk expressed before vaccination, across 2–3 weeks after the first dose, and across 3 weeks after the second dose. Women provided their blood, spotted on cards (dried blood spots), 19 days after the first dose and 21 days after the second dose. Stool samples from the breastfed infants were collected 21 days after mothers second vaccination. Prepandemic samples of milk, dried blood spots, and infant stool were used as controls. Milk, dry blood stains, and baby stools were tested for receptor-binding domain (RBD) -specific immunoglobulin (Ig) A and IgG using enzyme immunoassays. Milk samples were tested for the presence of neutralizing antibodies...
Read more

Management of Stillbirth

Image
Stillbirth is one of the maximum not unusualplace destructive being pregnant outcomes, happening in 1 in a hundred and sixty deliveries with inside the United States. In evolved countries, the maximum everyday threat elements related to stillbirth are non-Hispanic black race, nulliparity, superior maternal age, obesity, preexisting diabetes, persistent hypertension, smoking, alcohol use, having a being pregnant the usage of assisted reproductive technology, a couple of gestation, male fetal sex, single status, and beyond obstetric history. Although a number of those elements can be modifiable ( together with smoking), many are not. The have a look at of particular reasons of stillbirth has been hampered via way of means of the dearth of uniform protocols to assess and classify stillbirths and via way of means of reducing post-mortem rates. In any particular case, it is able to be hard to assign an exact motive to a stillbirth. A considerable sha...
Read more